On March 20, 2026, the White House released its National Policy Framework for Artificial Intelligence (“Framework”), outlining legislative recommendations for Congress to establish a unified federal approach to AI regulation. The Framework builds on prior executive actions, including the December 2025 Executive Order (the “Executive Order”) and the Trump administration’s “America’s AI Action Plan,” and it proposes that Congress adopt legislation broadly preempting state AI laws deemed to impose “undue burdens.” This alert summarizes the Framework’s key provisions, analyzes their potential impact on state laws, and highlights considerations for healthcare and life sciences stakeholders navigating the evolving regulatory landscape. While the Framework does not itself change the current legal status of the Executive Order, it signals increased policy focus and may prompt further agency action.